Keys and Gray recently announced their departure from the daily show after confirming they had accepted a new TV role with Al Jazeera’s English language channel.
Murray, who last season lost his Match of the Day 2 presenting role to Mark Chapman, will be taking over the 10am-1pm slot from August 12th.
Liam Fisher, programme director at talkSPORT, told RadioToday: “Colin Murray is a hugely talented sports broadcaster who brings further experience and creativity to our fantastic line-up.
“Our investment in sports rights and presenters continues to prove a winning combination and Colin’s addition comes at an exciting time following unparalleled exclusive British & Irish Lions coverage and the return of the Barclays Premier League next month.”
Murray’s new role means his time at 5 live will come to an end. The Northern Irishman first joined the station in 2006 and has helped to establish Fighting Talk as one of its most popular programmes, as well as being a regular presenter of 5 live Sport. He has also worked for Radio 1 and Channel 5.
He said: “I’m truly excited about creating this programme, and I hope it will become the morning ‘go to’ for UK sports fans. I will be joined by fascinating and knowledgeable guests every day offering up different opinions on issues and topics that you want to hear about throughout the week.
“I have thoroughly enjoyed working on my 5 live shows and with the BBC team and look forward to continuing my relationship with BBC Sport TV and 6 Music.”