The agency will be working on planning, insight, brand strategy, multi-channel creative and media.
Principle Hayley is based in Harrogate and has a collection of more than 50 hotels around the country.
James Parkinson, head of marketing at Principal Hayley Hotels, said: “Home won us over with a really impressive pitch, full of insight and fresh creative, and we’re looking forward to working with them.”
Sam Rainey, managing partner at Home, added: “We’re thrilled to have been chosen by Principal Hayley Hotels.
“They’ve got some seriously impressive hotels in their collection and we can’t wait to help bring their luxury brand proposition to life.
“It’s a huge account for us, with so much potential.”